Figure 5. Attenuated response to DSS-induced colitis in atg4b^−/− (WT) bone marrow chimeric mice. Four groups of bone marrow chimeric mice were used: WT (WT), atg4b^−/− (atg4b^−/−), WT (atg4b^−/−) and atg4b^−/− (WT). Chimeric mice were treated with 2.5% DSS in drinking water for 7 d followed by regular drinking water as indicated in Materials and Methods. (A) Percent body weight and (B) survival after DSS administration. (C) Clinical score data (see Materials and Methods). (D) Colon length and representative photographs of colon and cecum from WT (atg4b^−/−) (top) and atg4b^−/− (WT) (bottom) chimeric mice after DSS-induced colitis. The results shown are means ± SEM, n = 10 of each chimeric mice. Statistical significance was determined on last day of the experiment by one-way analysis of variance (ANOVA; A, C and D), and survival differences between groups were analyzed by Log-rank test (B) (*p < 0.05).