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. Author manuscript; available in PMC: 2014 Sep 1.
Published in final edited form as: Histochem Cell Biol. 2013 Jul 10;140(3):271–283. doi: 10.1007/s00418-013-1117-6

Figure 1.

Figure 1

COG complex interactome defines subunit specific hubs of regulated trafficking related proteins.

A comprehensive map of interactions between COG subunits and different trafficking related proteins. COG subunits can be classified by the groups of trafficking proteins that they interact with including SNAREs (blue), tethers (purple), Rabs (yellow) and coat and motor proteins (maroon). In this organization scheme we define the COG subunits as hubs for the class of protein that they interact with. COG subunits COG2 and COG3 are defined as “tether hubs”, COG2 COG3 and COG4 are defined as “coat and motor hubs”, COG4, COG5, and COG6 are defined as “Rab hubs”, and COG4, COG6, COG7, and COG8 are defined as “SNARE hubs”. Interestingly, COG1 has no other specific interactions therefore it is designated as the critical subunit for maintaining the structural integrity of the entire complex.