The COG complex assembles docking stations for retrograde intra-Golgi vesicles
Hypothetical model depicting how the COG complex may serve to assemble docking stations on Golgi membranes for incoming retrograde vesicles. In this model the COG complex (or COG sub-complexes) act to orchestrate the assembly of a pre-tethering protein complex through interactions with Rabs, coiled-coil tethers, and SNAREs. The targeting of a vesicle in this model is defined by the specific COG interactions, meaning the Rab, SNARE, or tether that are assembled into the docking complex.