Table 1.

COG interacting SNAREs and SNARE-interacting (SM) proteins

COG subunit	Partner protein	organism	Detection method*	Reference
COG2	Sed5	yeast	PD-W	(Suvorova et al. 2002)
COG3	Sed5	yeast	PD-W, PD-G	(Suvorova et al. 2002)
	STX5	human	Co-IP	(Sohda et al. 2010)
	YKT6	yeast	PD-W	(Suvorova et al. 2002)
	Gos1	yeast	PD-W	(Suvorova et al. 2002)
	Sec22	yeast	PD-W	(Suvorova et al. 2002)
	GS28 (GOSR1)	human	Co-IP	(Zolov and Lupashin 2005; Sohda et al. 2010)
COG4	Sed5	yeast	Y2H, Co-IP	(Shestakova et al. 2007)
	STX5	human	Y2H, Co-IP	(Shestakova et al. 2007; Willett et al. 2013; Sohda et al. 2010; Laufman et al. 2009; Laufman et al. 2013; Kudlyk et al. 2013)
	STX16	human	Co-IP, PD-W	(Laufman et al. 2013)
	Vti1a	human	Co-IP, PD-W	(Laufman et al. 2013)
	GS28 (GOSR1)	human	Co-IP, PD-W	(Laufman et al. 2013)
	Sly1	human	Co-IP, PD-W	(Laufman et al. 2009; Laufman et al. 2013)
	Vps45	human	Co-IP, PD-W	(Laufman et al. 2013)
COG6	STX5	human	Y2H, Co-IP	(Shestakova et al. 2007; Kudlyk et al. 2013; Laufman et al. 2013)
	STX6	human	Y2H, PD-W, Co-IP	(Laufman et al. 2011; Kudlyk et al. 2013; Willett et al. 2013)
	GS27 (GOSR2)	human	Y2H, Co-IP	(Kudlyk et al. 2013)
	SNAP29	human	Y2H, Co-IP	(Willett et al. 2013; Kudlyk et al. 2013)
COG7	STX6	human	Co-IP	(Laufman et al. 2013)
	STX16	human	Co-IP	(Laufman et al. 2013)
	GS28 (GOSR1)	human	Co-IP	(Laufman et al. 2013)
	GS15 (BET1L)	human	Co-IP	(Laufman et al. 2013)
	Vps45	human	Co-IP	(Laufman et al. 2013)
COG8	STX5	human	Y2H, Co-IP	(Willett et al. 2013)
	STX16	human	Y2H, Co-IP	(Laufman et al. 2013; Willett et al. 2013)
	GS27 (GOSR2)	human	Y2H, Co-IP	(Willett et al. 2013)

^*

Abbreviations used for detection method

• Y2H – yeast two hybrid
• Co-IP – co-immunoprecipitation
• PD-W – pull-down with subsequent Western Blot
• AC-MS – affinity capture with subsequent mass-speck analysis
• PD-G – pull-down with subsequent Gel staining
• PCA – protein fragment complementation assay