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HSP90 inhibition enhances regulatory T cell function in vitro via HSF1. Representative histograms of CellTrace-labeled CD4+ T cells co-cultured with decreasing concentrations of CD4+CD25+ Tregs from HSF1+/+ vehicle-treated mice or HSF1+/+ and HSF1−/− mice treated with 17-AAG. Proliferation of CD3-stimulated CD4+ co-cultured with Tregs from vehicle or 17-AAG-treated mice. Results representative of N=3 individual experiments with similar results.
