Table 1.
Partial list of genes affected by METH self-administration and withdrawal in the rat striatum.
| Gene Name | Gene Symbol | Expression Ratio METH / Yoked SAL | p value (ANOVA) | |
|---|---|---|---|---|
| 2h | 24h | |||
| Neurotrophic factors | ||||
| Heparin-binding EGF-like growth factor | Hbegf | 4.44 | 3.45 | 0.0406; 0.0114 |
| Brain derived neurotrophic factor | Bdnf | 3.28 | 1.33 | 0.0379 |
| Nerve growth factor, gamma | Ngfg | −2.31 | 2.22 | 0.0163 |
| Synoptic proteins | ||||
| Syntaxin 1A | Stx1a | 2.30 | −1.02 | 0.0074 |
| Synapsin II | Syn2 | 2.12 | −1.11 | 0.0433 |
| Synaptophysin | Syp | 1.74 | 1.20 | 0.0044 |
| Synaptojanin 2 | Synj2 | 1.73 | 1.29 | 0.0482 |
| Neuropeptides | ||||
| Cholecystokinin | Cck | 4.93 | 1.68 | 0.0022 |
| Neuromedin S | Nms | 4.41 | −1.01 | 0.0041 |
| Neuromedin U | Nmu | 3.84 | 1.35 | 0.0001 |
| Cortistatin | Cort | 3.53 | 1.19 | 0.0047 |
| Prepronociceptin | Pnoc | 3.42 | 1.23 | 0.0079 |
| Neurotensin | Nts | 3.08 | 1.05 | 0.0069 |
| Follistatin | Fst | 2.20 | 1.24 | 0.0001 |
| Prodynorphin | Pdyn | 1.79 | 1.26 | 0.0006 |
| Neuropeptide Y | Npy | 1.74 | 1.31 | 0.0112 |
| Receptors | ||||
| Glial cell line derived neurotrophic factor receptor alpha 1 | Gfra1 | 7.76 | 1.70 | 0.0048 |
| Gastrin releasing peptide receptor | Grpr | 7.08 | −2.05 | 0.0057 |
| Cholinergic receptor, nicotinic, alpha polypeptide 4 | Chrna4 | 5.60 | 1.17 | 0.0484 |
| Neuropeptide Y receptor Y1 | Npy1r | 2.35 | −1.31 | 0.0440 |
| Angiotensin receptor 1b | Agtr1b | 2.10 | −1.12 | 0.0048 |
| Relaxin/insulin-like family peptide receptor 1 | Rxfp1 | 1.88 | 1.27 | 0.0072 |
| Cholinergic receptor, muscarinic 3, cardiac | Chrm3 | 1.82 | 1.29 | 0.0217 |
| Fibroblast growth factor receptor-like 1 | Fgfrl1 | 1.81 | 1.27 | 0.0104 |
| Fibroblast growth factor receptor 4 | Fgfr4 | 1.35 | 3.51 | 0.0132 |
| Transporters | ||||
| Solute carrier family 8, member 1 | Slc8a1 | 7.56 | 1.37 | 0.0012 |
| Vesicular glutamate transporter 2 | Vglut2 | 6.30 | 1.77 | 0.0001 |
| Solute carrier family 37, member 1 | Slc37a1 | 6.07 | −1.05 | 0.0044 |
| Solute carrier family 9, isoform 3 regulator 2 | Slc9a3r2 | 5.60 | −1.11 | 0.0035 |
| Vesicular glutamate transporter 1 | Vglut2 | 3.95 | 2.06 | 0.0138 |
| Kinases/Phosphatases | ||||
| Ca2+/calmodulin-dependent kinase kinase 2, beta | Camkk2 | −1.23 | 1.93 | 0.0342 |
| Protein kinase C, delta | Prkcd | 1.34 | 1.75 | 0.0388 |
| Transcription factors | ||||
| Neuronal pentraxin 1 | Nptx1 | 4.82 | 1.37 | 0.0027 |
| Nuclear receptor subfamily 4, group A, member 1 | Nr4a1/Nurr77 | 2.03 | 1.02 | 0.0015 |
| Nuclear receptor subfamily 4, group A, member 3 | Nr4a3 | 1.99 | −1.01 | 0.0413 |
| Nuclear receptor subfamily 4, group A, member 2 | Nr4a2/Nurr1 | 1.92 | 1.51 | 0.0409 |
| FBJ murine osteosarcoma viral oncogene homolog | c-fos | 1.87 | 1.29 | 0.0424 |
| Jun oncogene | c-jun | 1.84 | 1.13 | 0.0155 |
| Neuronal pentraxin 2 | Nptx2 | 1.77 | 1.06 | 0.0213 |
| cAMP responsive element modulator | Crem | 1.72 | 1.02 | 0.0124 |
| FBJ osteosarcoma oncogene B | fosb | 1.72 | 1.27 | 0.0452 |