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. Author manuscript; available in PMC: 2014 Oct 1.
Published in final edited form as: Neurobiol Dis. 2013 May 6;58:3–12. doi: 10.1016/j.nbd.2013.04.020

Figure 2. Dendritic complexity in somatosensory cortex of Mecp2−/ymice.

Figure 2

(a) Sholl analysis of somatosensory cortex layer V pyramidal neurons in P30 WT (n=24 neurons from 4 mice) and Mecp2−/y mice (n=19 neurons from 4 mice) shows reduced dendritic complexity in Mecp2−/y mice relative to WT. Basal dendritic arbor is denoted b negative distance from soma, 0 urn marks soma position within cortex, and apical dendritic arbor is denoted by positive distance from soma. Two-way ANOVA with Bonferroni correction, p<0.0001 (interaction); *p<0.05, **p<0.01, ***p<0.001. Bars represent mean ± sem.

(b) Sholl analysis of somatosensory cortex layer V pyramidal neurons in P60 WT (n=36 neurons from 4 mice) and Mecp2−/y mice (n=31 neurons from 4 mice) show more widespread reduction in dendritic complexity in Mecp2−/y mice relative to WT than seen in P30 animals. Two-way ANOVA with Bonferroni correction, p<0.0001 (interaction); *p<0.05, ***p<0.001.