Table 1.
Baseline Characteristics of Normal Weight and Overweight/Obese Women
| Metabolically Benign Normal Weight (n = 251) | Metabolically Benign Overweight/Obese (n = 296) | At-Risk Overweight/Obese (n = 89) | |
|---|---|---|---|
|
|
|||
| Age, yrs | 52.9 ± 2.6 | 53.0 ± 2.5 | 53.0 ± 2.7 |
| Race-Ethnicity, % Caucasian | 82.3 | 78.3 | 74.4 |
| Current Smoking, % | 3.6 | 8.5 1 | 11.2 |
| Education, % ≥ College graduate | 74.0 | 70.2 | 64.0 |
| Systolic Blood Pressure, mmHg | 114.5 ± 15.6 | 118.4 ± 13.5 1,2 | 130.0 ± 13.7 |
| Diastolic Blood Pressure, mmHg | 72.6 ± 8.7 | 75.4 ± 8.8 1,2 | 80.1 ± 93 |
| Elevated Blood Pressure, % | 14.3 | 22.6 1,2 | 65.2 |
| Total Cholesterol, mg/dL | 215.6 ± 32.3 | 214.7 ± 31.5 | 215.8 ± 33.5 |
| HDL Cholesterol, mg/dL | 71.4 ± 16.0 | 64.5 ± 16.0 1,2 | 46.4 ± 9.0 |
| LDL Cholesterol, mg/dL | 124.8 ± 29.7 | 129.5 ± 27.6 1 | 134.2 ± 29.2 |
| Low HDL Cholesterol, % | 5.2 | 13.5 1,2 | 77.0 |
| Triglycerides, mg/dL | 70.6 ± 26.6 | 85.5 ± 36.31,2 | 165.2 ± 69.4 |
| Elevated Triglycerides, % | 1.2 | 4.1 1,2 | 59.8 |
| Glucose, mg/dL | 85.8 ± 8.7 | 89.5 ± 9.2 1,2 | 97.5 ± 10.6 |
| Elevated Glucose, % | 3.6 | 7.4 2 | 46.1 |
| Insulin, μU/mLa | 4.2 (2.9) | 5.8 (5.3) 1,2 | 9.2 (6.7) |
| BMI, kg/m2 | 22.3 ± 1.7 | 29.0 ± 2.9 1,2 | 30.6 ± 2.9 |
| Obese, n (%) BMI > 30 | 99 (33.4) | 50 (56) | |
| Waist Circumference, cm | 78.1 ± 19.7 | 92.4 ± 21.6 1,2 | 99.2 ± 25.1 |
| C-Reactive Protein, mg/dLa | 0.6 (0.9) | 1.7 (2.8) † 1 | 2.7 (3.7) |
| Physical Activity, METs per week | 25.6 ± 20.7 | 20.4 ± 19.2 1 | 19.3 ± 15.4 |
| HMW Adiponectina | 8.1 (5.6) | 6.02 (4.76)1,2 | 4.55 (3.39) |
| Leptina | 11.93 (10.65) | 27 (20.38)1,2 | 33.4 (21.9) |
| Soluble Leptin Receptora | 38.33 (10.89) | 30.98 (9.64)1,2 | 28.33 (9.46) |
Data are mean ± SD (for continuous variables) and percentages (for categorical variables).
a
Median (interquartile range).
1
P <0.05 vs. metabolically benign normal weight;
2
P <0.05 vs. at-risk overweight/obese
Metabolically Benign Phenotype Definition: ≤1 of: elevated blood pressure (≥130/85 mmHg), elevated TG (≥150 mg/dL), elevated fasting glucose (≥100 mg/dL), low HDL cholesterol (<50 mg/dL).