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. Author manuscript; available in PMC: 2014 Aug 1.
Published in final edited form as: Eur Neuropsychopharmacol. 2012 Aug 24;23(8):960–971. doi: 10.1016/j.euroneuro.2012.08.005

Figure 2.

Figure 2

Effects of SN79 on body temperature in the absence and presence of METH. Male, Swiss Webster mice (N = 5–10/group) were pretreated with saline (Sal) or SN79 (1, 3, 10 mg/kg, i.p.), and after 15 min, the mice were treated with Sal or METH (5, 10 mg/kg, i.p.). Core body temperature was measured 1 h after each injection combination. This regimen was repeated four times at 2 h intervals. A, effects of SN79 on basal body temperature. B, effects of pretreatment with SN79 on METH (5 mg/kg, i.p.)-induced hyperthermia. C, effects of pretreatment with SN79 on METH (10 mg/kg, i.p.)-induced hyperthermia. Data was reported as mean ± SEM. **P<0.01, ***P<0.001 vs. saline; #P<0.05, ##P<0.01, ###P<0.001 vs. METH.