Effects of SN79 on body temperature in the absence and presence of METH. Male, Swiss Webster mice (N = 5–10/group) were pretreated with saline (Sal) or SN79 (1, 3, 10 mg/kg, i.p.), and after 15 min, the mice were treated with Sal or METH (5, 10 mg/kg, i.p.). Core body temperature was measured 1 h after each injection combination. This regimen was repeated four times at 2 h intervals. A, effects of SN79 on basal body temperature. B, effects of pretreatment with SN79 on METH (5 mg/kg, i.p.)-induced hyperthermia. C, effects of pretreatment with SN79 on METH (10 mg/kg, i.p.)-induced hyperthermia. Data was reported as mean ± SEM. **P<0.01, ***P<0.001 vs. saline; #P<0.05, ##P<0.01, ###P<0.001 vs. METH.