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. Author manuscript; available in PMC: 2014 Aug 1.
Published in final edited form as: Eur Neuropsychopharmacol. 2012 Aug 24;23(8):960–971. doi: 10.1016/j.euroneuro.2012.08.005

Figure 3.

Figure 3

Effects of methamphetamine (METH) and SN79 on striatal dopamine levels. A, dose response of METH on dopamine (DA) levels in the striatum. Male, Swiss Webster mice (N = 5–9/group) were injected (i.p.) with METH (1.25- 5.0 mg/kg, i.p.) or saline (0 mg/kg, i.p.) at 2 h intervals for a total of four times. DA levels in the striatum were measured one week later. B, effects of SN79 on METH-induced depletion of DA levels in striatum of mouse brain tissue. Male, Swiss Webster mice (N = 5/group) were pretreated with saline or SN79 (1, 3, 10 mg/kg, i.p.). Mice were then treated with saline (-METH 0 mg/kg, i.p.) or METH (+METH 5 mg/kg, i.p.) after 15 min. This treatment regimen was repeated at 2 h intervals for a total of four times. Tissue samples from mouse striatum were collected and DA concentration was measured one week later. Data was reported as mean ± SEM. *P<0.05, ***P <0.001 vs. saline; ###P<0.001 vs. METH.