Table 1. Correlation of body temperature and striatal (A) dopamine and (B) 5-HT levels of mice pretreated with saline or SN79 (1–10 mg/kg) prior to saline or METH (5 and 10 mg/kg).
The values from individual mice were used to calculate the correlation between core body temperature (BT) at each of the four time points and striatal (A) dopamine (DA) and (B) 5-HT levels measured one week later. The table summarizes the mean ± S.E.M. for each of the groups, with the statistical results shown at the bottom. The numbers in the parentheses of the treatment group column represent doses (in mg/kg, i.p.) of SN79 or methamphetamine (METH).
| A. | |||||
|---|---|---|---|---|---|
| Treatment Group | DA (% Saline Control) |
BT1 | BT2 | BT3 | BT4 |
| Sal/Sal | 100 ± 6.9 | 37.86 ± 0.24 | 37.24 ± 0.29 | 37.06 ± 0.29 | 36.8 ± 0.30 |
| SN79(1)/Saline | 112.39 ± 4.55 | 37.76 ± 0.17 | 37.16 ± 0.14 | 36.92 ± 0.19 | 36.9 ± 0.26 |
| SN79(3)/Saline | 112.04 ± 4.75 | 37.06 ± 0.33 | 36.78 ± 0.31 | 36.78 ± 0.41 | 36.8 ± 0.26 |
| SN79(10)/Saline | 111.87 ± 4.7 | 35.2 ± 0.48 | 35.42 ± 0.41 | 35.54 ± 0.35 | 35.6 ± 0.33 |
| Saline/METH(5) | 41.95 ± 6.59 | 37.96 ± 0.23 | 38.14 ± 0.19 | 38.86 ± 0.34 | 39.62 ±0.32 |
| SN79(1)/METH(5) | 105.58 ± 3.70 | 37.32 ± 0.26 | 37.14 ± 0.23 | 37.24 ± 0.39 | 37.52 ± 0.24 |
| SN79(3)/METH(5) | 108.48 ± 4.53 | 36.38 ± 0.36 | 36.26 ± 0.36 | 36.02 ± 0.32 | 36.8 ± 0.35 |
| SN79(10)/METH(5) | 119.58 ± 4.76 | 34.94 ± 0.32 | 35.8 ± 0.38 | 36.24 ± 0.32 | 36.16 ± 0.35 |
| P | <0.01 | <0.0005 | <0.0001 | <0.0001 | |
| Pearson r | −0.4164 | −0.5291 | −0.5819 | −0.7555 | |
| r2 | 0.1734 | 0.28 | 0.3386 | 0.5708 | |
| B. | |||||
|---|---|---|---|---|---|
| Treatment Group | 5-HT (% Saline Control) |
BT1 | BT2 | BT3 | BT4 |
| Sal/Sal | 100 ± 6.86 | 37.14 ± 0.19 | 36.82 ± 0.15 | 36.65 ± 0.20 | 37 ± 0.19 |
| SN79(1)/Saline | 115.59 ± 7.95 | 37.32 ± 0.20 | 37.12 ± 0.20 | 36.99 ± 0.16 | 37.24 ± 0.12 |
| SN79(3)/Saline | 107.58 ± 6.70 | 37.4 ± 0.15 | 37.11 ± 0.13 | 36.94 ± 0.14 | 37.14 ± 0.13 |
| SN79(10)/Saline | 99.51 ± 11.80 | 35.85 ± 0.31 | 35.46 ± 0.36 | 35.72 ± 0.36 | 35.6 ± 0.34 |
| Saline/METH(10) | 55.76 ± 6.14 | 38.78 ± 0.22 | 38.45 ± 0.20 | 39.17 ± 0.18 | 38.83 ± 0.34 |
| SN79(1)/METH(10) | 93.18 ± 5.63 | 38.56 ± 0.14 | 37.37 ± 0.22 | 37.9 ± 0.27 | 38.16 ± 0.31 |
| SN79(3)/METH(10) | 95.81 ± 6.91 | 37.31 ± 0.27 | 36.43 ± 0.34 | 37.27 ± 0.34 | 37.53 ± 0.33 |
| SN79(10)/METH(10) | 108.08 ± 8.83 | 35.88 ± 0.26 | 36.33 ± 0.24 | 36.71 ± 0.18 | 36.63 ± 0.17 |
| P | <0.01 | <0.005 | <0.001 | <0.05 | |
| Pearson r | −0.3025 | −0.3208 | −0.3735 | −0.2875 | |
| r2 | 0.09152 | 0.1029 | 0.1395 | 0.08267 | |