Fig. 1.

Assessment of circadian rhythm parameters: five month old wt (white) and tg MSA (gray) animals show differences in day–night-rhythm in their home cage regarding A) locomotor activity [expressed as counts per minute (counts/min)], B) HR [expressed as beats per minute (BPM)] and C) temperature [°C]. Especially regarding the activity levels, tg MSA animals do not show the characteristic day–night-fluctuations e.g. their circadian rhythm is blunted and clearly differs from wt animals. Black bars indicate active night periods, and white bars indicate day phases. Data plotted are means ± S.E.M., n(tg) = 9, n(wt) = 6 animals.