Table 1.
Allele Frequencies of Nonsynonymous Polymorphisms in NADPH Oxidase Genes.
| Genes | rs | Minor Allele (Amino Acid) | Polyphen Prediction | African | European | Asian | Hispanic |
|---|---|---|---|---|---|---|---|
| CYBA | |||||||
| Y72H | rs4673 | T (Y) | Possibly damaging | 0.46 | 0.32 | 0.17 | 0.22 |
| V174A | rs1049254 | T (V) | Benign | 0.17 | 0.48 | 0.48 | 0.18 |
| NCF2 | |||||||
| K181R | rs2274064 | G (R) | Benign | 0.35 | 0.37 | 0.41 | 0.48 |
| T279M | rs13306581 | T (T) | Probably damaging | 0.00 | 0.00 | 0.05 | 0.00 |
| V297A | rs35937854 | C (A) | Benign | 0.04 | 0.00 | 0.00 | 0.00 |
| T361S | Chr1:181799289 NCBI36/hg18 | T (S) | — | 0.00 | 0.00 | 0.02 | 0.00 |
| H389Q | rs17849502 | A (Q) | Benign | 0.00 | 0.05 | 0.00 | 0.07 |
| R395W | rs13306575 | T (W) | Possibly damaging | 0.00 | 0.00 | 0.00 | 0.07 |
| N419I | rs35012521 | T (I) | Probably damaging | 0.00 | 0.02 | 0.04 | 0.00 |
| P454S | rs55761650 | T (S) | — | 0.00 | 0.00 | 0.00 | 0.02 |
| L487S | Chr1:181795862 NCBI36/hg18 | C (S) | — | 0.02 | 0.00 | 0.00 | 0.00 |
| NCF4 | |||||||
| T85N | rs112306225 | A (N) | — | 0.00 | 0.00 | 0.02 | 0.00 |
| A304E | rs5995361 | A (E) | Benign | 0.04 | 0.00 | 0.00 | 0.00 |