Figure 1.
Algorithm for suggested clinical actions based on CYP2C19 genotype when considering treatment with clopidogrel for ACS patients undergoing PCI (ACS/PCI). 1Other rare CYP2C19 genotypes exist beyond those illustrated (see Supplementary Materials and Methods online for other genotypes and frequencies). 2Note that prasugrel and ticagrelor are recommended only when not contraindicated clinically. ACS, acute coronary syndrome; EM, extensive metabolizer; IM, intermediate metabolizer; PCI, percutaneous coronary intervention; PM, poor metabolizer; UM, ultrarapid metabolizer.