Table 1.
Top 10 Upregulated Transcripts in Term Amniotic Fluid
| Symbol | Gene Name | Gene Function | Tissue Specificity* | Fold Change |
Benjamini- Hochberg P |
|---|---|---|---|---|---|
| MUC7 | mucin 7, secreted | May function in a protective capacity by promoting the clearance of bacteria in the oral cavity and aiding in mastication, speech, and swallowing | Salivary gland > 30 MoM, trachea >10 MoM | 1019.92 | < 1×10−15 |
| SFTPC | surfactant protein C | Pulmonary surfactant associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces | Lung > 30 Mom, fetal lung > 10 MoM | 424.49 | < 1×10−15 |
| STATH | statherin | Salivary protein that stabilizes saliva supersaturated with calcium salts | Salivary gland > 30 MoM, trachea >10 MoM | 416.19 | < 1×10−15 |
| RPTN | repetin | Involved in the cornified cell envelope formation. Multifunctional epidermal matrix protein. | NA | 288.74 | 8.21×10−12 |
| SLC34A2 | solute carrier family 34 (sodium phosphate), member 2 | May have a role in the synthesis of surfactant in lungs' alveoli | Lung > 30 MoM | 251.31 | < 1×10−15 |
| HTN3 | histatin 3 | Salivary proteins that are considered to be major precursors of the protective proteinaceous structure on tooth surfaces (enamel pellicle); exhibit antibacterial and antifungal activities | Salivary gland > 30 MoM | 238.93 | < 1×10−15 |
| GKN1 | gastrokine 1 | Has mitogenic activity and may be involved in maintaining the integrity of the gastric mucosal epithelium | Not organ specific | 161.50 | < 1×10−15 |
| SFTPA2 | surfactant protein A2 | Binds to surfactant phospholipids and is essential for normal respiration | Lung > 30 MoM | 152.73 | 6.86×10−14 |
| MSMB | microseminoprotein, beta- | Member of the immunoglobulin binding factor family. This protein has inhibin-like activity. | Prostate > 30 MoM, trachea > 10 MoM | 130.93 | < 1×10−15 |
| SFTPD | surfactant protein D | Contributes to pulmonary defense against inhaled microorganisms. May participate in the extracellular reorganization or turnover of pulmonary surfactant. | Lung > 30 MoM | 99.05 | < 1×10−15 |
MoM, multiples of the median; NA, not applicable.
Gene functions obtained from public databases (UniProtKB available at www.uniprot.org and Entrez Gene available at www.ncbi.nlm.nih.gov/gene). The information has been modified from the source due to space limitations.
*
Tissue specificity as mapped in the BioGPS gene expression atlas (http://biogps.gnf.org).