Table 4.
Genotype differences identified between fasting glucose, lipid profile, and DUSP1 gene variations.
| rs13184134 | rs7702178 | rs881150 | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Phenotypes | Meansa | P valuesb | Meansa | P valuesb | Meansa | P valuesb | ||||||
| Common HMZ | HTZ | Rare HMZ | Common HMZ | HTZ | Rare HMZ | Common HMZ | HTZ | Rare HMZ | ||||
| Fasting glucose (mM) | 6.48 ± 2.20 | 6.62 ± 2.52 | 7.36 ± 3.23 | 0.04 | 6.51 ± 2.24 | 6.61 ± 2.49 | 7.26 ± 3.20 | 0.01 | 6.60 ± 2.35 | 6.46 ± 2.34 | 6.63 ± 2.46 | 0.99 |
| Lipid profile | ||||||||||||
| Total-C (mM) | 4.68 ± 0.95 | 4.67 ± 0.95 | 4.51 ± 1.00 | 0.67 | 4.67 ± 0.95 | 4.67 ± 0.96 | 4.49 ± 1.03 | 0.33 | 4.65 ± 0.95 | 4.72 ± 0.92 | 4.61 ± 1.10 | 0.81 |
| LDL-C (mM) | 2.66 ± 0.82 | 2.67 ± 0.84 | 2.51 ± 0.86 | 0.63 | 2.65 ± 0.82 | 2.66 ± 0.85 | 2.50 ± 0.88 | 0.22 | 2.63 ± 0.84 | 2.71 ± 0.79 | 2.62 ± 0.94 | 0.51 |
| HDL-C (mM) | 1.23 ± 0.37 | 1.24 ± 0.32 | 1.24 ± 0.29 | 0.39 | 1.23 ± 0.37 | 1.25 ± 0.33 | 1.25 ± 0.30 | 0.44 | 1.25 ± 0.35 | 1.23 ± 0.35 | 1.18 ± 0.34 | 0.01 |
| TG (mM) | 1.84 ± 1.16 | 1.77 ± 0.86 | 1.80 ± 0.85 | 0.95 | 1.84 ± 1.16 | 1.76 ± 0.86 | 1.79 ± 0.89 | 0.98 | 1.81 ± 1.07 | 1.80 ± 0.98 | 1.91 ± 1.48 | 0.93 |
| Total-C/HDL-C | 4.05 ± 1.34 | 3.98 ± 118 | 3.76 ± 0.96 | 0.32 | 4.04 ± 1.35 | 3.94 ± 1.18 | 3.73 ± 0.97 | 0.36 | 3.94 ± 1.17 | 4.10 ± 1.46 | 4.14 ± 1.32 | 0.07 |
| Blood pressure | ||||||||||||
| SBP (mm Hg) | 138.7 ± 17.0 | 137.6 ± 16.0 | 136.1 ± 18.7 | 0.46 | 138.5 ± 16.9 | 137.9 ± 16.1 | 134.4 ± 17.9 | 0.38 | 138.3 ± 17.2 | 138.7 ± 16.2 | 137.4 ± 17.9 | 0.65 |
| DBP (mm Hg) | 83.4 ± 11.3 | 83.6 ± 10.9 | 81.3 ± 11.1 | 0.42 | 83.4 ± 11.3 | 83.7 ± 11.0 | 80.5 ± 11.8 | 0.25 | 83.3 ± 11.3 | 83.8 ± 11.0 | 82.7 ± 11.9 | 0.70 |
Boldface values represent statistically significant results (P ≤ 0.05).
aValues presented (means ± SD) are untransformed and unadjusted.
b P values obtained are adjusted for the effect of age, sex, and BMI.
HMZ: homozygote; HTZ: heterozygote; Total-C: total cholesterol; LDL-C: low-density lipoprotein cholesterol; HDL-C: high-density lipoprotein cholesterol; TG: triglycerides; SBP: systolic blood pressure; DBP: diastolic blood pressure.