Table 3.

Equivalent invariant residues between the HCV template and the Dengue virus polymerase model in the vicinity of the ssRNA fragment or the UTP substrate.

Substrate	ssRNA			UTP
Interacting invariant RdRp residues	HCV RdRp structure	Dengue virus Model	Motif	HCV RdRp structure	Dengue virus Model	Motif
	D220	D312	IV	D318	D441	VI
	D318	D441	VI	D319	D442	VI
	D319	D442	VI	D220	D312	IV
	N291	N388	V	K155	K247	II
	T287	T384	V
	R158	R250	II
	E143	E327	I
	S282	S379	V
	K141	K235	I
	R168	R260	II
	R394	R515	Conserved