Table 3.
Putative KEGG pathways affected by miR clusters in 22q11.2 deletion syndrome patients.a
| Cluster
| |
|---|---|
| Pathway name | p-Value |
| 22q11.2 CL1 #1-20b | |
| ECM–receptor interaction | 1.09E−18 |
| Glycosaminoglycan biosynthesis — heparan sulfate | 1.07E−16 |
| Prion diseases | 1.25E−11 |
| TGF-beta signaling pathway | 2.85E−09 |
| Glioma | 6.26E−07 |
| Pathways in cancer | 7.63E−06 |
| Fatty acid biosynthesis | 1.13E−05 |
| Focal adhesion | 9.89E−05 |
| Endocytosis | 9.89E−05 |
| Neurotrophin signaling pathway | 9.89E−05 |
| Gap junction | 2.18E−04 |
| Pancreatic cancer | 2.18E−04 |
| Lysine degradation | 3.40E−04 |
| Small cell lung cancer | 3.40E−04 |
| Prostate cancer | 3.97E−04 |
| MAPK signaling pathway | 7.82E−04 |
| Non-small cell lung cancer | 8.95E−04 |
| Axon guidance | 1.36E−03 |
| ErbB signaling pathway | 2.13E−03 |
| Melanogenesis | 3.02E−03 |
| Wnt signaling pathway | 3.29E−03 |
| Amoebiasis | 3.93E−03 |
| 22q11.2 CL2 #21-34c | |
| ECM–receptor interaction | 2.93E−12 |
| Glycosaminoglycan biosynthesis — heparan sulfate | 1.03E−09 |
| Mucin type O-glycan biosynthesis | 1.71E−05 |
| TGF-beta signaling pathway | 1.83E−04 |
| Adherens junction | 3.29E−04 |
| Axon guidance | 5.08E−04 |
| Endocytosis | 5.23E−04 |
| 22q11.2 CL3 #35-50d | |
| Glycosaminoglycan biosynthesis — heparan sulfate | 1.68E−33 |
| Prion diseases | 6.51E−14 |
| TGF-beta signaling pathway | 9.14E−05 |
| ErbB signaling pathway | 9.14E−05 |
| Long-term depression | 1.78E−04 |
| Arrhythmogenic right ventricular cardiomyopathy (ARVC) | 3.54E−04 |
| Pathways in cancer | 2.07E−03 |
| Adherens junction | 2.95E−03 |
| Colorectal cancer | 3.10E−03 |
| Endocytosis | 4.00E−03 |
| 22q11.2 CL4 #51-57e | |
| Fatty acid biosynthesis | 1.26E−28 |
| Glycosaminoglycan biosynthesis - heparan sulfate | 2.89E−21 |
We used publicly available DIANA miRPath v2.0 to identify affected molecular pathways by miR clusters as detailed in the methods section.
miR-155, miR-28-5p, miR-142-3p, miR-335, miR-19a, miR-7, miR-374b, miR-148a, miR-29b, miR-21, miR-182, miR-183, miR-215, miR-29a, miR-146b-5p, miR-29c, miR-30e-3p, miR-27b, miR-374a, miR-424.
miR-940, miR-1238, miR-1913, miR-625-3p, miR-1237, miR-1249, miR-1281, miR-1825, miR-1234, miR-296-5p, miR-425-3p, miR-1228, miR-409-3p, miR-423-3p.
miR-324-5p, miR-222, miR-140-3p, miR-424-3p, miR-550a-3p, miR-1914-3p, miR-548 h, miR-486-3p, miR-331-3p, miR-610, miR-432, miR-148a-5p, miR-425, miR-103a-2-5p, miR-1307, miR-33b-3p.
miR-663, miR-505-5p, miR-584, miR-1180, miR-503, miR-18b-3p, miR-210.