Table 4.

Human miR expression differences between normal controls and 22q11.2 deletion syndrome patients with cardiac anomalies, hypocalcemia and low CD3⁺ T cell counts.

MicroRNAa		Normal		22q11.2 Δ		Associative p-valueb	Ratiod	MiR regulatory functions
		Average	SD	Average	SD
Congenital heart disease	miR-185	7655	2810	2841	1309	0.00E+00c	0.37	Mammalian organogenesis
	miR-15b-3p	35	33	119	100	0.00E+00c	3.41	Cardiomyocyte mitotic arrest
	miR-150	12,808	11,015	5494	3006	2.48E−10	0.43	Cardiomyocyte cell growth
	miR-720	851	993	342	210	2.19E−09	0.40	Epithelial cell development
	miR-194	134	102	262	182	8.13E−08	1.96	Epithelial cell differentiation
	miR-324-5p	182	65	342	290	1.22E−07	1.88	Hedgehog signaling
	let-7b	3722	4770	1334	803	3.51E−07	0.36	Cell survival
	miR-363	650	364	1044	563	2.75E−05	1.61	Cardiomyocyte apoptosis
	let-7 g	3122	2486	1849	896	3.25E−04	0.59	Heart development
	let-7i	3368	2217	2088	1248	5.54E−04	0.62	Heart development
	miR-23b	1039	490	1583	712	7.52E−04	1.52	Morphogenesis
	miR-361-5p	188	87	297	208	3.90E−03	1.58	Chronic heart failure marker
Hypocalcemia	miR-185	7655	2810	2889	1380	0.00E+00b	0.38	Cell cycle and DNA methylation
	miR-150	12,808	11,015	5061	2793	1.09E−12	0.40	Cell cycle signaling
	miR-15b-3p	35	33	124	114	6.91E−11	3.54	Cellular ATP levels
	miR-21	41	53	169	286	1.16E−09	4.09	Cell proliferation
	miR-324-5p	182	65	343	246	2.01E−09	1.88	As above
	let-7b	3722	4770	1467	730	1.64E−04	0.39	As above
	miR-720	851	993	326	233	4.29E−07	0.38	As above
	miR-194	134	102	268	193	1.85E−06	2.01	As above
	let-7i	3368	2217	2098	1032	3.50E−03	0.62	As above
	miR-145	55	33	35	17	3.44E−03	0.63	Smooth muscle cell function
Low CD3+ T cell counte	miR-185	7655	2810	2981	1317	0.00E+00b	0.39	B cell autoantibody production
	miR-15b-3p	35	33	119	107	1.07E−11	3.41	Cell survival
	miR-324-5p	182	65	365	260	6.46E−11	2.00	As above
	miR-21	41	53	181	292	1.90E−09	4.36	Immune activation and tolerance
	miR-150	12,808	11,015	6336	3198	3.66E−08	0.49	T and B cell development
	miR-720	851	993	320	236	7.19E−07	0.38	As above
	miR-194	134	102	254	179	7.00E−06	1.90	Follicular lymphoma cell growth
	let-7b	3722	4770	1347	804	3.76E−05	0.36	IFN-beta production
	miR-29a	17	11	36	38	5.89E−05	2.06	IFN-gamma production
	miR-361-5p	188	87	317	235	4.58E−04	1.69	Deregulated in blood cells

^aMicroRNA refers to human microRNAs and let represents an early miR designation.

^bAssociative p values.

^cAssociative p-value is less than 10^−12.

^dRatio is the normal miR level divided by the 22q11.2 deletion syndrome miR levels.

^eLow CD3 levels are defined to be less than 2 SD compared with age-matched controls.