Table 5.
Trabecular bone morphology of left (contralateral) and right (“loaded”) tibia from C57BL/6 and BALB/c mice over 6 weeks
| Parameter | Strain | Time [wk] |
AC | WashU | Cornell/HSS | |||
|---|---|---|---|---|---|---|---|---|
| Left | Right | Left | Right | Left | Right | |||
| Trabecular BV/TV [%]G, T | C57BL/6 | 0 | 12.1±0.9 | 11.8±1.5 | 11.5±1.3 | 11.1±2.5 | 11.2±1.6 | 10.6±1.3 |
| 3 | 11.2±1.1 | 10.8±1.3 | 11.4±1.5 | 10.1±2.3* | 11.8±1.2 | 11.5±1.6 | ||
| 6 | 10.1±0.9 | 9.5±1.3 | 9.8±1.1 | 11.6±2.0‡ | 10.3±1.1 | 16.8±2.1*,a,b,†,‡ | ||
| BALB/c | 0 | 19.4±3.7 | 18.6±4.3 | 21.1±2.0 | 20.0±2.6 | 19.8±2.4 | 18.9±2.7 | |
| 3 | 18.6±2.9 | 17.2±3.7 | 18.6±3.1 | 18.4±3.9 | 17.8±4.5 | 18.2±3.1 | ||
| 6 | 17.6±3.1 | 17.3±3.3 | 18.1±2.7 | 20.8±3.0*,† | 15.2±4.4 | 22.9±3.4*,a,b,†,‡ | ||
| Tb.Th [µm]G, T, M | C57BL/6 | 0 | 50±2 | 48±3 | 49±2 | 50±5 | 50±2 | 48±2* |
| 3 | 53±2 | 52±3 | 51±3 | 57±1*,a | 52±3 | 65±3*,a,b,† | ||
| 6 | 57±4 | 56±4 | 52±3 | 72±6*, a,†,‡ | 55±4 | 89±9*,a,b,†,‡ | ||
| BALB/c | 0 | 58±5 | 56±5 | 60±1 | 59±3 | 58±3 | 57±3* | |
| 3 | 59±4 | 56±5* | 58±2 | 57±5# | 56±3 | 61±4*,a,b,# | ||
| 6 | 62±3 | 58±4* | 59±3 | 69±6*,a,†,‡,# | 57±4c | 80±7*,a,b,†,‡,# | ||
| Tb.N [mm−1]T | C57BL/6 | 0 | 4.4±0.3 | 4.3±0.3 | 4.3±0.3 | 4.3±0.4 | 4.3±0.3 | 4.3±0.3 |
| 3 | 4.0±0.2 | 4.0±0.3 | 4.1±0.4 | 4.1±0.3 | 4.1±0.2 | 4.2±0.5 | ||
| 6 | 3.7±0.3 | 3.7±0.3 | 4.0±0.3 | 3.9±0.2 | 4.1±0.3 | 4.0±0.2 | ||
| BALB/c | 0 | 5.1±0.4 | 4.9±0.4 | 5.3±0.4 | 5.1±0.2 | 5.3±0.4 | 5.0±0.4 | |
| 3 | 4.7±0.4 | 4.6±0.3 | 4.8±0.4 | 4.9±0.4 | 5.1±0.8 | 4.9±0.5 | ||
| 6 | 4.3±0.4 | 4.3±0.4 | 4.6±0.5 | 4.7±0.4 | 4.3±0.8 | 4.7±0.6*,†,‡ | ||
| vBMD [mg HA·cm−3]G, T, M | C57BL/6 | 0 | 141±10 | 136±12 | 140±9 | 130±20 | 139±10 | 125±12* |
| 3 | 133±10 | 123±14 | 138±10 | 117±23* | 145±18 | 128±14 | ||
| 6 | 125±13 | 119±12 | 126±12 | 129±11 | 133±11 | 163±18*,a,b,†,‡ | ||
| BALB/c | 0 | 202±26 | 191±30 | 214±17 | 201±17 | 204±19 | 193±14* | |
| 3 | 195±20 | 178±30 | 195±21 | 189±28 | 190±36 | 192±18 | ||
| 6 | 187±21 | 180±23 | 190±19 | 208±23 | 168±35 | 224±22*,a,b,†,‡ |
Data are presented as mean±SD.
: Difference between left (contralateral) and right (“loaded”) tibia;
: main effect of group,
: relative change (Loaded vs Contralateral, %) different from AC of same mouse strain and time,
: relative change different from WashU of same mouse strain and time,
: absolute value of contralateral outcome different from contralateral of AC from same mouse;
: main effect of time,
: relative change different from 0 week of same group and mouse,
: relative change of 6wk different from 3 week of same group and mouse,
: main effect of mouse strain,
: relative change different from C57BL/6 of same group and time; p<0.05.