(A-D’) Sections of whole mount in situ hybridizations of Xenopus embryos at stage 39 with miR-200 (A,A’), zeb2 (B,B’), miR-30 (C,C’) and snai1 (D,D’). Close-ups show the pronephric kidney. e, epidermis; pn, pronephros. (E,F) Schematic diagrams illustrating the role of E-box transcription factors and miR-30/miR-200 in the formation of renal epithelial tubules during kidney development (E) and their imbalance in response to injury (F).