Table 5.
Noncompartmental Pharmacokinetic Analyses of DBC-11,12-Diol in Naïve and Pregnant Mice
| Tissue | AUC (µM·h) | AUC ratio | T(1/2) (h) | T MAX (h) | C MAX (µM) | C MAX ratio | % of dose | % of dose ratio | |
|---|---|---|---|---|---|---|---|---|---|
| Blood | Naïve | 0.6 | 1.43 | 14.0 | 3.0 | 0.046±0.008 | 2.92 | 0.0042±0.0007 | 2.07 |
| Pregnant | 0.9 | 7.5 | 2.5 | 0.135±0.136 | 0.0087±0.0087 | ||||
| Liver | Naïve | 4.0 | 0.78 | 31.9 | 2.5 | 0.382±0.051 | 0.98 | 0.038±0.00018 | 0.93 |
| Pregnant | 3.1 | 9.6 | 3.0 | 0.376±0.011 | 0.035±0.0011 | ||||
| Lung | Naïve | 4.0 | 1.76 | 8.7 | 2.0 | 0.403±0.02 | 1.93 | 0.0036±0.00018 | 2.00 |
| Pregnant | 7.1 | 5.8 | 3.5 | 0.776±0.159 | 0.0073±0.0015 | ||||
| Fat | Naïve | 0.5 | 2.46 | 6.6 | 3.0 | 0.081±0.053 | 1.30 | 0.0081±0.0053 | 1.22 |
| Pregnant | 1.1 | 28.3 | 4.0 | 0.105±0.032 | 0.0099±0.0030 | ||||
| Intestine | Naïve | 9.2 | 1.54 | 21.0 | 3.5 | 1.17±0.44 | 0.97 | 0.053±0.020 | 0.69 |
| Pregnant | 14.2 | 59.8 | 4.0 | 1.13±0.18 | 0.037±0.0058 | ||||
| Placenta | Pregnant | 3.8 | — | 10.6 | 6.0 | 0.361±0.185 | — | 0.024±0.0086 | — |
| Fetus | Pregnant | 2.5 | — | 12.4 | 6.0 | 0.16±0.026 | — | 0.084±0.016 | — |