Table 7.
Reduction (Fold Change) in P450 Enzyme Activities in Pregnant Versus Naïve Mice
| Enzyme | Naïve vs. pregnant |
|---|---|
| Fold difference | |
| CYP17A1 | 0.35 |
| CYP1A1 | 5.62 |
| CYP1A2 | 5.37 |
| CYP2C37 | 8.43 |
| CYP2C38 | 2.86 |
| CYP2C39 | 2.00 |
| CYP2C40 | 2.90 |
| CYP2C54 | 5.97 |
| CYP2C70 | 1.30 |
| CYP27A1 | 4.63 |
| CYP2A4 | 2.39 |
| CYP2A5 | 2.40 |
| CYP 2A12 | 2.21 |
| CYP2B9 | 5.71 |
| CYP2B10 | 1.94 |
| CYP2B19 | 5.44 |
| CYP2C29 | 2.15 |
| CYP2D9 | 1.43 |
| CYP2D10 | 1.34 |
| CYP2D11 | 1.42 |
| CYP2D26 | 1.33 |
| CYP2E1 | 6.58 |
| CYP2F2 | 4.79 |
| CYP2J5 | 1.48 |
| CYP2J6 | 1.49 |
| CYP3A41 | 0.96 |
| CYP3A11 | 1.71 |
| CYP3A13 | 1.81 |
| CYP3A16 | 1.37 |
| CYP3A25 | 0.59 |
| CYP4A10 | — |
| CYP4A14 | 30.05 |
| CYP4A12A | — |
| CYP4F14 | 4.34 |
| CYP51A1 | 1.18 |
| Average change | 3.74±5.1 |