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. 2013 Jun 20;135(1):72–80. doi: 10.1093/toxsci/kft136

Fig. 5.

Fig. 5.

Ni reduces eNOS dimerization through induction of oxidative stress in HUVECs. HUVECs were treated with Ni (10μM) for the indicated time (A and C) or the indicated concentration of Ni for 48h (B and D). The eNOS dimerization (A and B) and the expression levels of HO-1 protein (C and D) were analyzed by Western blot. (E) HUVECs were treated with Ni (10μM) and/or Tiron (200mM), and eNOS dimerization was analyzed by Western blot. A representative image of two or three independent experiments is presented.