Table 1.
Comparison of features between classical apoptosis and mitochondrial superoxide-induced neuronal cell death.
| Classical apoptosis |
Mitochondrial superoxide-induced neuronal cell death |
|
|---|---|---|
| • Loss of plasma membrane asymmetry |
Yes | Yes |
| • Mitochondrial permeability change |
Yes | Yes |
| • Rapid mitochondrial swelling and damage |
No | Yes |
| • Cytochrome C release | Yes | Yes |
| • Dependence on cellular ATP | Yes | No |
| • DNA fragmentation | Yes | Yes |
| • DNA fragmenting enzymes involved |
||
| Caspases 3/9 activation | Yes | No |
| Caspase-activated DNase (CAD) | Yes | No |
| AIF | No | Yes |
| EndoG | No | Yes |