Table 3.

 High dimensional propensity score analysis*. Figures are odds ratios and 95% confidence intervals adjusted for 10ths of propensity score, comparing risk for postpartum hemorrhage in pregnant women with current antidepressant exposure

	Total†	No (%) of women with postpartum hemorrhage	Covariates in propensity score model
			Delivery year	Investigator defined‡	Investigator defined‡ and empirically defined
SRI monotherapy	10 203	415 (4.1)	1.46 (1.32 to 1.61)	1.47 (1.32 to 1.64)	1.52 (1.35 to 1.71)
Unexposed	53 348	1479 (2.8)	Reference	Reference	Reference
Non-SRI monotherapy	1162	45 (3.9)	1.39 (1.06 to 1.82)	1.49 (1.12 to 1.98)	1.39 (1.03 to 1.89)
Unexposed	52192	1475 (2.8)	Reference	Reference	Reference

SRI=serotonin reuptake inhibitor.

*Women with highest and lowest 2.5% of propensity score excluded from analyses.

†Numbers are for trimmed population in investigator defined and empirically defined covariates analysis.

‡Investigator defined covariates: delivery year, age, race, multiple pregnancy, diabetes, coagulopathy, number of outpatient mood/anxiety disorder diagnoses, number of inpatient mood/anxiety disorder diagnoses, psychotic disorder, other mental health disorder, pain indication, sleep disorder, anticonvulsant dispensing, benzodiazepine dispensing, aspirin dispensing, heparin dispensing, low molecular weight heparin dispensing, and number of outpatient visits and days in hospital during baseline.