Figure 1.

Differential antibody responses to outer surface protein A (OspA) and Borrelia iron and copper-binding protein A (BicA) in American and European Lyme borreliosis patients. Serum samples from normal controls (NC) or patients with erythema migrans (EM), Lyme neuroborreliosis (LNB), Lyme arthritis (LA), or acrodermatitis chronica atrophicans (ACA) were analyzed for immunoglobulin (Ig)G responses to Borrelia burgdorferi (Bb) lysate (A), OspA (B), and BicA (C). The American LA patients were subdivided into 2 groups based on whether the arthritis was responsive (Rsp.) or refractory (Rfr.) to antibiotic therapy. The circles represent individual serum samples and the bars represent the medians. The ratio of positive/total number of samples tested and the percentage of positive samples are shown for each group at the top.