Figure 3.

Cryptococcal mannoprotein (CMP)- and mitogen-activated T cells detected in whole blood from patients with cryptococcosis-associated immune reconstitution inflammatory syndrome (C-IRIS) or neurological deterioration (ND) using flow cytometry. Percentage of CD25+CD134+CD4+ T cells following stimulation with mitogen (A) or CMP (B) in whole blood from patients with C-IRIS (grey box) and no ND (open box) prior to and during 24 weeks of combination antiretroviral therapy. Absolute numbers of CMP-activated CD25+CD134+CD4+ T cells per microliter blood are also shown (C). The corrected data (after subtraction of values in unstimulated cultures) are shown as a box-and-whisker plot with the median and 25th and 75th percentiles shown as the middle, lower, and upper lines of the box, respectively. P values are indicated as *P < .0500, **P < .0100, ***P < .0010, and ****P < .0001.