Figure 4.

Cryptococcal mannoprotein (CMP)–induced interferon-gamma (IFN-γ) production in whole blood cultures from patients with cryptococcosis-associated immune reconstitution inflammatory syndrome (C-IRIS) or no neurological deterioration (ND) before and during combination antiretroviral therapy. IFN-γ levels in plasma after 24 hours (A) or 5 days (B) of culture are shown for patients with C-IRIS (grey box) or no ND (white box). The corrected data (after subtraction of values in unstimulated cultures) are shown as a box-and-whisker plot with the median and 25th and 75th percentiles shown as the middle, lower, and upper lines of the box, respectively. P values are indicated as *P < .0500, **P < .0100, ***P < .0010, and ****P < .0001.