Figure 5.

Pre-combination antiretroviral therapy (cART) cryptococcal mannoprotein (CMP)–specific T-cell and cytokine/chemokine responses in patients who did (open box) or did not (grey box) survive the first 24 weeks of cART. (A) Percentage of CD4+ T cells that expressed CD25+ and CD134+ when unstimulated or following stimulation with mitogen or CMP. (B) Levels of CMP-induced interferon-gamma, CXCL10, or IL-10 in plasma from 24-hour (left panel) or 5-day (right panel) whole blood cultures. The corrected data (after subtraction of values for unstimulated cultures) are shown as a box-and-whisker plot with the median and 25th and 75th percentiles shown as the middle, lower, and upper lines of the box, respectively. P values are indicated as *P < .0500, **P < .0100, ***P < .0010, and ****P < .0001.