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. 2013 Aug 21;8(8):e73644. doi: 10.1371/journal.pone.0073644

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© 2013 Feldman et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Successful depletion of Tregs in Ig-α ^-/- mice. PC61 (anti-CD25 depleting antibody) was administered to RRV-infected mice on day of life 4. Representative dot plots show PC61 Treg depletion. (B) Serum direct bilirubin (mean ±SD). *P<.001 vs. Ig-α^-/- RRV+ PC61 and Ig-α^-/- RRV+ rat serum. (C) Liver immune cell profile. Mice were sacrificed at 2 weeks of age and immune cells were identified based on CD45 expression.