Table 2. Association of the Pro12Ala polymorphism with type 2 diabetes mellitus.
Allele and genotype | D2TM (%) | Controls (%) | Crude OR (95% CI), P | Adjusted OR (95% CI), P |
Pro/Pro | 1060 (92.6) | 1783 (89.1) | 1.00 | 1.00 |
Pro/Ala and Ala/Ala | 85 (7.4) | 218 (10.9) | 0.63 (0.48–0.81), 0.001 | 0.64 (0.49–0.83), 0.001 |
Pro | 2201 (96.1) | 3779 (94.4) | 1.00 | 1.00 |
Ala | 89 (3.9) | 223 (5.6) | 0.67 (0.52–0.86), 0.002 | 0.69 (0.54–0.88), 0.003 |
Adjusted for age, sex, BMI, hypertension, and family history of diabetes.
Abbreviations: CI, confidence interval; OR, odds ratio. The other abbreviations used see Table 1.