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. 2013 Aug 21;8(8):e70393. doi: 10.1371/journal.pone.0070393

Table 8. Functional annotation clustering of genes upregulated during stage I and then downregulated during stage II of lactogenesis.

Category Term N Percent(%) P-Value
Cluster 1 Enrichment Score: 2.48
GOTERM_BP_FAT GO:0007049 cell cycle 11 10.68 7.85E-06
GOTERM_BP_FAT GO:0022402 cell cycle process 9 8.74 2.51E-05
GOTERM_BP_FAT GO:0022403 cell cycle phase 8 7.77 3.66E-05
GOTERM_BP_FAT GO:0000279 M phase 7 6.80 9.29E-05
GOTERM_BP_FAT GO:0000278 mitotic cell cycle 7 6.80 1.03E-04
GOTERM_BP_FAT GO:0000280 nuclear division 6 5.83 1.77E-04
GOTERM_BP_FAT GO:0007067 mitosis 6 5.83 1.77E-04
SP_PIR_KEYWORDS cell division 7 6.80 2.23E-04
GOTERM_BP_FAT GO:0000087 M phase of mitotic cell cycle 6 5.83 2.24E-04
GOTERM_BP_FAT GO:0048285 organelle fission 6 5.83 2.37E-04
GOTERM_BP_FAT GO:0051301 cell division 6 5.83 0.00
GOTERM_CC_FAT GO:0000775 chromosome, centromeric region 5 4.85 0.00
SP_PIR_KEYWORDS cell cycle 7 6.80 0.00
SP_PIR_KEYWORDS mitosis 5 4.85 0.00
GOTERM_CC_FAT GO:0005694 chromosome 8 7.77 0.00
GOTERM_CC_FAT GO:0044427 chromosomal part 7 6.80 0.01
GOTERM_CC_FAT GO:0005819 spindle 4 3.88 0.01
GOTERM_CC_FAT GO:0015630 microtubule cytoskeleton 6 5.83 0.03
GOTERM_BP_FAT GO:0007017 microtubule-based process 4 3.88 0.06
GOTERM_CC_FAT GO:0000793 condensed chromosome 3 2.91 0.06
SP_PIR_KEYWORDS cytoskeleton 5 4.85 0.10
GOTERM_CC_FAT GO:0043228 non-membrane-bounded organelle 13 12.62 0.18
GOTERM_CC_FAT GO:0043232 intracellular non-membrane-bounded organelle 13 12.62 0.18
GOTERM_CC_FAT GO:0005874 microtubule 3 2.91 0.19
GOTERM_CC_FAT GO:0044430 cytoskeletal part 6 5.83 0.21
GOTERM_CC_FAT GO:0005856 cytoskeleton 7 6.80 0.30
SP_PIR_KEYWORDS cytoplasm 10 9.71 0.69
Cluster 2 Enrichment Score: 2.34
GOTERM_MF_FAT GO:0048037∼cofactor binding 9 8.74 3.42E-05
GOTERM_MF_FAT GO:0050662∼coenzyme binding 5 4.85 0.01
GOTERM_BP_FAT GO:0055114∼oxidation reduction 6 5.83 0.261
Cluster 3 Enrichment Score: 1.71
GOTERM_MF_FAT GO:0030554∼adenyl nucleotide binding 20 19.42 4.08E-05
GOTERM_MF_FAT GO:0001883∼purine nucleoside binding 20 19.42 4.63E-05
GOTERM_MF_FAT GO:0001882∼nucleoside binding 20 19.42 5.00E-05
GOTERM_MF_FAT GO:0032559∼adenyl ribonucleotide binding 17 16.50 7.63E-04
GOTERM_MF_FAT GO:0017076∼purine nucleotide binding 20 19.42 8.58E-04
GOTERM_MF_FAT GO:0005524∼ATP binding 16 15.53 0.00
SP_PIR_KEYWORDS atp-binding 13 12.62 0.00
GOTERM_MF_FAT GO:0000166∼nucleotide binding 21 20.39 0.00
GOTERM_MF_FAT GO:0032553∼ribonucleotide binding 17 16.50 0.01
GOTERM_MF_FAT GO:0032555∼purine ribonucleotide binding 17 16.50 0.01
INTERPRO IPR017441:Protein kinase, ATP binding site 6 5.83 0.03
INTERPRO IPR000719:Protein kinase, core 6 5.83 0.06
SP_PIR_KEYWORDS nucleotide-binding 12 11.65 0.06
GOTERM_MF_FAT GO:0004674∼protein serine/threonine kinase activity 5 4.85 0.11
GOTERM_MF_FAT GO:0004672∼protein kinase activity 6 5.83 0.15
SP_PIR_KEYWORDS serine/threonine-protein kinase 4 3.88 0.15
GOTERM_BP_FAT GO:0006468∼protein amino acid phosphorylation 6 5.83 0.18
INTERPRO IPR008271:Serine/threonine protein kinase, active site 4 3.88 0.19
SMART SM00220:S_TKc 3 2.91 0.22
INTERPRO IPR017442:Serine/threonine protein kinase-related 4 3.88 0.24
GOTERM_BP_FAT GO:0016310∼phosphorylation 6 5.83 0.27
INTERPRO IPR002290:Serine/threonine protein kinase 3 2.91 0.29
SP_PIR_KEYWORDS kinase 4 3.88 0.42
GOTERM_BP_FAT GO:0006793∼phosphorus metabolic process 6 5.83 0.44
GOTERM_BP_FAT GO:0006796∼phosphate metabolic process 6 5.83 0.44
Cluster 4 Enrichment Score: 1.37
GOTERM_BP_FAT GO:0006259∼DNA metabolic process 7 6.80 0.01
GOTERM_BP_FAT GO:0006281∼DNA repair 4 3.88 0.06
GOTERM_BP_FAT GO:0033554∼cellular response to stress 5 4.85 0.07
GOTERM_BP_FAT GO:0006974∼response to DNA damage stimulus 4 3.88 0.10
Cluster 5 Enrichment Score: 1.28
GOTERM_BP_FAT GO:0008203∼cholesterol metabolic process 3 2.91 0.03
GOTERM_BP_FAT GO:0016125∼sterol metabolic process 3 2.91 0.04
GOTERM_BP_FAT GO:0008202∼steroid metabolic process 3 2.91 0.11