Table 2. List of polymeric therapeutics and conjugates those are currently under clinical development.
| S. no. | Product Name | Description | Clinical use |
|---|---|---|---|
| 1. |
VivaGel |
Lysine-based dendrimer |
Microbiocide |
| 2. |
CT-2103; Xyotax |
Poly glutamic acid |
Cancer |
| 3. |
Opaxio |
(PGA)-paclitaxel |
Cancer |
| 4. |
Prolindac |
(HPMA-copolymer-DACH platinate) |
Cancer |
| 5. |
NKTR-102 |
(PEG-irinotecan conjugate) |
Cancer-metastatic breast |
| 6. |
PEG-SN38 |
(Multiarm PEG-camptothecan derivative) |
Cancer |
| 7. |
NKTR-118 |
(PEG-naloxone) |
Opioid-induced constipation |
| 8. | XMT-1001 | (poly(1-hydroxymethylethylene hydroxymethylformal) -camptothecin conjugate) | Cancer |
PGA, Poly glutamic acid; HPMA, N-(2-Hydroxypropyl)methacrylamide; DACH, cytotoxic diaminocyclohexane. Modified from reference 51