Table 6.
Associations between Patient Characteristics and KRAS Mutation
| Variable | #positive/#tested | Percentage | Fisher’s Exact p value |
|---|---|---|---|
| Gender | 0.01 | ||
| Male | 32/154 | 20.8% | |
| Female | 73/220 | 33.2% | |
| Race | 0.09 | ||
| African American | 13/52 | 25.0% | |
| Caucasian | 86/281 | 30.6% | |
| Asian American | 0/15 | 0.0% | |
| Hispanic | 1/2 | 50.0% | |
| Other | 3/16 | 18.8% | |
| Race, binary | 0.51 | ||
| African American | 13/52 | 25.0% | |
| Caucasian | 86/281 | 30.6% | |
| Smoking status | <0.001 | ||
| Never Smoker | 6/72 | 8.3% | |
| Ever Smoker | 98/300 | 32.7% | |
| Histology | 0.68 | ||
| Adenocarcinoma | 88/294 | 29.9% | |
| Squamous | 5/31 | 16.1% | |
| Adenosquamous | 4/12 | 33.3% | |
| Poorly Differentiated | 5/24 | 20.8% | |
| Large Cell | 2/8 | 25.0% | |
| Sarcomatoid | 0/1 | 0.0% | |
| Pleomorphic | 0/1 | 0.0% | |
| NOS* | 0 | -- | |
| Disease Status | 0.03 | ||
| Localized | 23/92 | 25.0% | |
| Recurrent, extrathoracic | 6/18 | 33.3% | |
| Recurrent, intrathoracic | 17/33 | 51.5% | |
| Metastatic extrathoracic | 35/147 | 23.8% | |
| Metastatic intrathoracic | 24/83 | 28.9% | |
| Subcutaneous Mets | 0.02 | ||
| No | 101/365 | 27.7% | |
| Yes | 4/5 | 80.0% | |
| Surgery as part of treatment | 0.05 | ||
| No | 43/183 | 23.5% | |
| Yes | 62/187 | 33.2% |
*
NOS refers to NSCLC not otherwise specified