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. Author manuscript; available in PMC: 2014 Oct 13.
Published in final edited form as: Free Radic Biol Med. 2013 Apr 24;0:320–332. doi: 10.1016/j.freeradbiomed.2013.04.015

Table 1.

Grading system for clinical assessment of mice after GBS infectiona

State normal moribund dead
Score 1 2 3 4 5 6
Activity active less active slowed movement slowed inactive, wobbly, unable to walk dead
Coat smooth rough rough, starred rough, starred rough, starred dead
Eyes clear clear dull some crusting closed, crusted dead
Breathing normal normal, slowed slowed labored labored, shallow none
Posture good some hunching hunched hunched lying on side none
Isolation none none none possible isolation isolation dead
Handling resists some resistance less resistance minimal resistance little or no resistance dead
a

Mice were inoculated with GBS i.p., and scored for disease severity according to the score index given above. Moribund mice were given a score of 5 and dead mice were given a score of 6.