Table 4.

Survival of WT and Gsr^−/− mice at 72 h after LPS challenge^a

LPS (mg/kg)	Survived (total challenged)
	WT	Gsr−/−
7.5	5 (5)	5 (5)
10	5 (5)	5 (5)
15	8 (15)	13 (15)
20	2 (7)	2 (6)
25	1 (2)	0 (2)
30	0 (12)	3 (12)
35	0 (2)	0 (2)

^aMice were challenged i.p. with the indicated doses of LPS.

LD₅₀ was calculated by logistic regression.

LD₅₀ wt= 16.2 mg/kg body weight; LD₅₀ Gsr= 20.7 mg/kg body weight.