Table 2.
Correlation of biomarkers with disease activity, determined by endoscopy.
| Author | Patient population | Assessment of endoscopic disease activity | Lactoferrin (correlation coefficient) | Calprotectin (correlation coefficient) | CRP (correlation coefficient) |
|---|---|---|---|---|---|
| Sipponen50 (2008) | CD | CDEIS | 0.77 | 0.73 | 0.55 |
| D'Inca51 (2007) | CD | SES-CD | 0.19 | 0.48 | |
| D'Inca51 (2007) | UC | Mayo score | 0.35 | 0.51 | |
| Hanai 200452 | UC | Matt's Index | 0.81 | ||
| Siponnen53 (2008) | CD | SES-CD | 0.63 | 0.64 | 0.52 |
| Fagerberg54 (2007) | IBD | Saverymuttu114 | 0.52 | ||
| Roseth48 (1997) | UC | Mayo score | 0.57 | ||
| Jones55 (2008) | CD | SES-CD | 0.76 | 0.72 | 0.46 |
| Sipponen56 (2008) | CD | CDEIS | 0.87 | 0.83 | 0.61 |
| Schoepfer58 (2009) | UC | Rachmilewitz Index | 0.83 | 0.50 | |
| Schoepfer57 (2010) | CD | CDEIS | 0.75 | 0.53 |
CDEIS – Crohn's Disease Endoscopic Index of Severity; SES-CD - Simple Endoscopic Score for Crohn's Disease