. Author manuscript; available in PMC: 2013 Aug 21.

Published in final edited form as: Gastroenterology. 2011 May;140(6):1817–1826.e2. doi: 10.1053/j.gastro.2010.11.058

Table 3.

Sensitivity and specificity of biomarkers to identify active disease, based on endoscopy.

Author	Patient population	Assessment of endoscopic disease activity	Lactoferrin (Sensitivity / Specificit)	Calprotectin (Sensitivity / Specificity)	CRP (Sensitivity / Specificit)
Roseth^#49 (2004)	CD and UC	Farup method¹¹⁵		100% / 100%
Solem⁶² (2005)	CD	Study specific index^##			54% / 75%
Siponnen^* (2008)⁵⁹	CD	CDEIS	77% / 100%	87% / 100%
Siponnen^60† (2008)	CD	CDEIS	66%-71% / 83%-92%	70%-91% / 44%-92%	48% / 91%
Siponnen^61‡ (2010)	CD	SES-CD	80% / 67%	80% / 89%
D'Inca^**⁵¹ (2007)	CD	SES-CD	77% / 80%	81% / 80%
D'Inca^**⁵¹ (2007)	UC	Mayo score	75% / 60%	78% / 70%
Schoepfer^††58 (2009)	UC	Rachmilewitz Index		86% - 93% / 71% - 88%
Schoepfer^#57 (2010)	CD	CDEIS		89% / 58%	68%/58%

CDEIS – Crohn's Disease Endoscopic Index of Severity

SES-CD - Simple Endoscopic Score for Crohn's Disease

Threshold concentrations - calprotectin 50 μg/g

Threshold concentrations - calprotectin 200 μg/g; lactoferrin 10 μg/g

^†

Threshold concentrations - calprotectin 50-200 μg/g; lactoferrin 7.25 – 10 μg/g

^‡

Threshold concentrations - calprotectin 100 μg/g; lactoferrin 7.25 μg/g

^##

Findings of erosions or ulcerations; spontaneous bleeding; exudate; inflammatoryappearing nodularity, masses, or fistulas; friability; granularity; cobblestoning; extensive erythema; and concomitant erythema with edema.

^**

Threshold concentrations - calprotectin 80 μg/g; lactoferrin not specified in μg/g

^††

Threshold concentrations - calprotectin 50-100 μg/g