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. Author manuscript; available in PMC: 2013 Aug 21.
Published in final edited form as: Trends Biotechnol. 2011 Feb 4;29(4):159–166. doi: 10.1016/j.tibtech.2011.01.002

Figure 3.

Figure 3

Crystallographic B-factors mapped onto X-ray structures of 1m4w designs. WT protein (1m4w_WT) and 2 design variants (1m4w_6 and 1m4w_6w20v48) are shown as ribbon diagrams, in which the width and color are proportional to the B-factor at each residue (values increase from blue to red and as ribbon gets wider). The protein resembles a hand with the binding pocket located in a cleft between the ‘thumb’ and ‘fingers’. Higher B-factors in the thumb and fingers of the designed structures indicate a shift in the dynamics of the binding pocket.