FIG. 4.
Indices of glucose metabolism, disposal, and insulin sensitivity prior to and after short-term administration of olanzapine, aripiprazole, or placebo. Olanzapine administration had no effect on EGP during the basal period or during steady state but significantly reduced glucose disposal (Rd) (P < 0.05) and the GIR (P < 0.05) (A). Aripiprazole similarly reduced glucose disposal and the GIR (P < 0.05) (B) compared with placebo (C). The AIR to the meal was calculated as the first 10 min of insulin release. Olanzapine (D) but not aripiprazole (E) significantly increased AIRmeal compared with placebo (F). Both olanzapine and aripiprazole decreased insulin sensitivity (P < 0.05) but the DI was not significantly different after the intervention, demonstrating adequate compensation for the prevailing insulin resistance. SI was calculated as the change in glucose disposal and dividing by the change in insulin and multiplying by glucose at steady state. DI was estimated by multiplying the SI by the AIR to the meal. Values are mean ± SEM. *P < 0.05.