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. 2013 Aug 15;62(9):3151–3162. doi: 10.2337/db13-0305

FIG. 5.

FIG. 5.

Attenuation of key features of DN at 22 weeks in diabetic miR-192–KO mice. A: Western blot and quantification of p53 expression in cortical lysates of WT or miR-192-KO mice (control or STZ-diabetic for 22 weeks). Control mice, n = 3 per group; diabetic mice, n = 4 per group. Representative immunostaining and quantification of TGF-β and p53(B), PAS staining (C), and Masson’s trichrome staining (D) from cortical sections of WT and miR-192–KO control or STZ-diabetic mice; n = 3–6 mice per group. E: Urine protein levels at 19 weeks post–diabetes induction from WT and miR-192–KO control or STZ-injected mice (WT-C, n = 6; WT STZ-diabetic, n = 6; KO-C, n = 3; KO-STZ, n = 6). F: Bar graph showing relative ACR levels at 19 weeks post–diabetes induction from urine samples of WT or miR-192-KO mice (control or STZ-diabetic) (WT-C, n = 5; WT STZ-diabetic, n = 5; KO-C, n = 3; KO-STZ, n = 5). *P < 0.05; **P < 0.01; ***P < 0.001. Error bars, SEM. Scale bar, 20 μm.