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13C MR spectra acquired from ex vivo rat liver samples, and from a solution of cholesterol in chloroform. (A) Wild type; (B) LAL deficient; (C) sebelipase α-treated LAL deficient; (D) 1.2 M cholesterol dissolved in chloroform. Resonances from the terminal methyl group of fatty acid chains (14.1 ppm) and from the cholesterol-C18 resonance (11.8 ppm) are highlighted.
