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. 2001 Jul 10;98(15):8674–8679. doi: 10.1073/pnas.141234898

Figure 1.

Figure 1

Expression of Tbx19 in pituitary development. (A) Nucleotide sequence of murine Tbx19 cDNA ORF predicts a 446-aa gene product containing a T-box (boxed). Reverse lettering on amino acid 147 indicates the site of mutation for Fig. 5 (N → T). (B) In situ hybridization using Tbx19 or POMC probes demonstrates expression of Tbx19 on e11.5 (open arrowhead) in the caudoventral aspect of developing anterior pituitary, followed by expression of POMC in Tbx19-expressing cells by e12–e12.5. Tbx19 expression is apparently restricted to POMC lineages. In ventral diencephalon, Tbx19 (closed arrowhead) is expressed from ≈e10.5, late in the arcuate and paraventricular nucleus, but is not expressed in the lateral regions of the arcuate nucleus where POMC is expressed (closed arrowhead).