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. 2013 Jul 19;154(9):3031–3042. doi: 10.1210/en.2012-2195

Figure 3.

Figure 3.

Micro-CT results for CaSR-cKO and control mice. A–D, Trabecular micro-CT results. A, Results for bone mass as measured by BV/TV. There is no difference between the CaSR-cKO and control mice. B, Results for BMD in CaSR-cKO and control mice. Note that BMD is significantly reduced in the CaSR-cKO bones. C and D, Three-dimensional reconstructions of trabecular bone from the proximal tibia of control and CaSR-cKO lactating mice. E–P, Cortical micro-CT results. E, Results for overall cortical bone mass (micro-CT threshold 350–1000) as measured by BV/TV. There is no difference between the CaSR-cKO and control mice. F, Results for cortical BMD in CaSR-cKO and control mice. Note that BMD is significantly reduced in the CaSR-cKO bones. G and H, Three-dimensional reconstructions of representative cortical bone from the tibia of control and CaSR-cKO lactating mice. I, Results for low-mineral-density (micro-CT threshold 350–630) cortical bone mass (Bv/TV). There is an increase in low-mineral-density bone in the CaSR-cKO mice. J, Results for BMD of low-density bone in CaSR-cKO and control mice. BMD is significantly reduced in the CaSR-cKO bones. K and L, Three-dimensional reconstructions of representative low-mineral-density bone in the tibial cortex of control and CaSR-cKO lactating mice. In controls the low-mineral-density bone is located mostly at the endosteal and periosteal surfaces, but in the CaSR-cKO mice, it is more evenly distributed throughout the entire cortex. M, Results for high-mineral-density (micro-CT threshold 630–1000) cortical bone mass (Bv/TV). There is a decrease in high-mineral-density bone in the CaSR-cKO mice. N, Results for BMD of high-mineral-density bone in CaSR-cKO and control mice. BMD is significantly reduced in the CaSR-cKO bones. O and P, Three-dimensional reconstructions of representative high-density bone in the tibial cortex of control and CaSR-cKO lactating mice. There is a clear and uniform reduction in high-mineral-density bone throughout the cortex. In all instances, values represent the means ± SEM for 12 controls and 9 CaSR-cKO mice. *, P < .05; **, P < .01; ***, P < .001.