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. 2013 Jul 19;154(9):3031–3042. doi: 10.1210/en.2012-2195

Figure 5.

Figure 5.

Loss of the mammary CaSR alters maternal calcium homeostasis during lactation. A, Serum calcium in control and CaSR-cKO mice on days 2 and 11 of lactation. The CaSR-cKO mice are transiently hypercalcemic in early lactation. Bars represent the mean ± SEM for 7 mice of each genotype. B, Circulating PTH levels in control and CaSR-cKO mice on day 12 of lactation. PTH levels are suppressed in lactating cKO mice. Bars represent the mean ± SEM for 7 mice of each genotype. C, Urinary calcium levels corrected for creatinine in control and CaSR-cKO mice on day 12 of lactation. Urinary calcium excretion is increased in lactating cKO mice. Bars represent the mean ± SEM for 13 mice of each genotype. D, 1,25 Dihydroxyvitamin D levels in control and CaSR-cKO mice on day 12 of lactation. Vitamin D levels were unchanged in lactating CaSR-cKO mice. Bars represent the mean ± SEM for 6 mice of each genotype. E, Serum calcium in rescued CaSR−/− mice on day 12 of lactation. C+P+ represents WT controls; C+P− represents PTH−/− mice; and C−P− represents CaSR−/−;PTH−/− mice. Note the persistent hypercalcemia in the C−P− cohort. Bars represent the mean ± SEM for 5 mice of each genotype. F, Urinary calcium corrected for creatinine in rescued CaSR−/− mice on day 12 of lactation. Note that relative to C+P+ mice, urinary calcium levels are increased in C+P− mice but not in C−P− mice. Bars represent the mean ± SEM for 5 mice of each genotype.