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. 2013 Jul 19;154(9):3031–3042. doi: 10.1210/en.2012-2195

Figure 6.

Figure 6.

Loss of the mammary CaSR inhibits calcium transport into milk and clearance of calcium from the circulation in lactating mice. A, Milk calcium concentrations in control and CaSR-cKO mice on day 12 of lactation. Milk calcium is reduced in CaSR-cKO mice. Bars represent the mean ± SEM for 5 mice of each genotype. B, Shown are the serum calcium levels measured 30 minutes after IP calcium doses in control virgin mice, control lactating mice, and CaSR-cKO mice. In virgin mice, the administration of increasing doses of ip calcium results in progressive hypercalcemia. However, in lactating controls, calcium is quickly cleared from the circulation. Loss of the mammary CaSR impairs calcium clearance and reverts the lactating pattern back to that of a virgin mouse, demonstrating that the enhanced calcium clearance during lactation depends on the CaSR in the mammary gland. Bars represent the mean ± SEM for 3 mice of each genotype at each dose of ip calcium.