Table 1.
Regulation of gene expression by TH in skin cells.
| Keratin genes | TH regulation | Cellular system | Reference |
|---|---|---|---|
| K5 | ↓ | Normal human epidermal keratinocytes | (115) |
| K14 | ↓ | Normal human epidermal keratinocytes, human HFs | (63, 115) |
| K6 | ↑ | Human epidermal keratinocytes (HaCat), human HFs | (63, 64) |
| K16 | ↑ | Human epidermal keratinocytes (HaCat) | (64) |
| K17 | ↓, ↑ | Human epidermal keratinocytes (HaCat) | (64, 115) |
| K15 | ↑ | Human epithelial HF stem cells | (119, 120) |
| Other (TH-responsive) genes | |||
| Cyclin D1 | ↑, ↓ | Mouse/human epidermal keratinocytes, human epithelial HF stem cells | (96, 107, 120, 121) |
| P19, p27 | ↑ | Mouse epidermal keratinocytes | (107) |
| AP1, NF-KB, STAT3 | ↓ | Mouse epidermal keratinocytes | (107) |
| TGF-β2 | ↓ | Mouse epidermal keratinocytes | (107) |
| AKR | ↑ | Human skin fibroblasts | (123) |
| RAB3B | ↑ | Human skin fibroblasts | (123) |
| COLVIA3-COLVIIIA1 | ↑ | Human skin fibroblasts | (123) |
| ENO1 | ↑ | Human skin fibroblasts | (123) |
| HIF-1α | ↑ | Human skin fibroblasts | (123) |
| ENO1 | ↑ | Human skin fibroblasts | (123) |
| ZAKI 4α | ↑ | Human skin fibroblasts | (123) |
| GLUT-1 | ↑ | Human skin fibroblasts | (123) |
| FGF7 | ↓ | Human skin fibroblasts | (123) |
| ADH1B | ↓ | Human skin fibroblasts | (123) |
| HAS2 | ↓ | Dermal cells | (124) |
| Integrin β4 | ↓ | Human epidermal keratinocytes | (125) |
| Plectin | ↓ | Human epidermal keratinocytes | (125) |
| COLXVII | ↓ | Human epidermal keratinocytes | (125) |