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. 2013 Aug 22;4:234. doi: 10.3389/fmicb.2013.00234

FIGURE 1.

FIGURE 1

Endogenous CIITA inhibits both HTLV-1 and HTLV-2 gene expression. (A) CIITA-negative U937 plus clone, CIITA-positive U937 minus clone, and U937 plus clone stably expressing fCIITA (U937 plus fCIITA) were transfected with the pACH plasmid containing the entire HTLV-1 genome. The amount of HTLV-1 p19 antigen (pg/ml) in cells supernatants was detected by enzyme-linked immunoassay (ELISA) 48 h post-transfection. Error bars indicate standard deviations. Derived from Tosi et al. (2011). (B) CIITA-positive Raji cells, their CIITA-negative isogenic mutant RJ2.2.5, and the RJfCIITA cells stably transfected with CIITA were infected with the HTLV-2 Gu strain 2b and the productive infection was evaluated by the presence of HTLV-2 p19 antigen (pg/ml) in cell culture supernatants measured by (ELISA). Error bars indicate standard deviations. Derived from Casoli et al. (2004).