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. 2013 Aug 22;4:234. doi: 10.3389/fmicb.2013.00234

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Copyright © Forlani, Abdallah, Accolla and Tosi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic representation of CIITA regions involved in the suppression ofTax function and in CIITA-Tax association. At the top is a diagram of CIITA with its domains: AD, activation domain; P/S/T, proline/serine/threonine-rich domain; GBD, GTP-binding domain; and LRR, leucine-rich repeats. The black box represents the minimal domain from positions 64–144 that is necessary to block the transcription function of Tax (Tax-inhibition, middle). Hatched (positions 1–252) and gray (positions 253–410) boxes represent the two regions of CIITA interacting with Tax (Tax interaction, bottom).